Facts & Risks

Abstract
Background: As of 2024, cannabis legalization in Northern American countries has spurred industry growth, intersecting with alcohol, tobacco, and pharmaceuticals. This study examines the investments and employee movement between five cannabis companies and alcohol, tobacco and pharmaceutical companies in order to explore the connections between the industries. While these relationships may bolster cannabis businesses, they also pose risks such as profit-driven practices that could undermine public health protections.

ABSTRACT
Introduction
Although more U.S. states continue to legalize the sale of cannabis for recreational adult-use, little is known about the spatial distribution of cannabis retailers in relation to neighborhood characteristics. The objective of this study is to examine the presence or absence of cannabis retailers in census tracts in relation to measures of neighborhood advantage and disadvantage.

Key Points
Question Are recent cannabis use and lifetime cannabis use associated with differences in brain function during cognitive tasks?

Findings In this cross-sectional study of 1003 young adults, heavy lifetime cannabis use was associated with lower brain activation during a working memory task; this association remained after removing individuals with recent cannabis use. These results were not explained by differences in demographic variables, age at first cannabis use, alcohol use, or nicotine use.

Meaning These findings suggest that cannabis use is associated with short- and long-term brain function outcomes, especially during working memory tasks.

Abstract
This study investigated trends in suspected cannabinoid hyperemesis syndrome (CHS)-related emergency department visits among youth (15–24 years old) in the United States between 2006 and 2020. Using data from the Nationwide Emergency Room Sample, over 55,000 suspected CHS-related visits were identified, with an average annual increase of 28.1% per year. This aligns with rising cannabis use and potency across the nation. Subjects in the western region, males, and those with public insurance were more likely to present with suspected CHS. These findings highlight the growing public health concern of CHS and emphasize the need for increased awareness among healthcare providers, particularly regarding the potential link between CHS and chronic cannabis use in youth. Further research is needed to understand the underlying mechanisms and risk factors associated with CHS as well as the impact of cannabis public policy on health outcomes.

Abstract
Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the availability and consumption of cannabis. Cannabinoids are touted to have therapeutic potential for many diseases and could be a replacement for opioids for analgesia and sedation. However, cannabinoids can cause substantial adverse cardiovascular events that would mitigate any potential benefit. The endocannabinoid system regulates mood, satiety and memory, and modulates the cardiovascular system. The link between cannabinoids and cardiovascular disease, which used to be limited to evidence from preclinical studies, case reports and case series, is now evident in epidemiological studies. Cannabinoids adversely affect the cardiovascular system, causing myocardial infarction, cerebrovascular accidents, arrhythmia and heart failure. The effects of novel cannabinoids are unknown, and synthetic cannabinoids have the potential to cause even more substantial harm than traditional cannabinoids. Therefore, with the increasing availability and use of cannabis, the acute and chronic effects of this drug are becoming apparent.